题目：A new method for detecting DNA copy number variations using the next-generation sequencing data
        主讲人：陈洁教授
        Department of Biostatistics
        Georgia Regents University
        时间：2014年12月17日星期三上午 9:00-11:00
        地点：重庆大学A区生物工程学院212会议室

       讲座内容：
        To study the genetic reasons of tumor growth, cancer formation, and genetic diseases, researchers now use advanced technologies, such as the comparative genomic hybridization (CGH), the array-based comparative genomic hybridization (aCGH), and the next generation sequencing (NGS), to conduct DNA copy number experiments for detecting DNA copy number variations (CNVs) as cancer development, genetic disorders, and many other diseases are usually relevant to CNVs on the genome.   Identifying boundaries of CNV regions on a chromosome or a genome can be viewed as a change point problem of detecting signal/intensity changes presented in the genomic data.  The analysis of high throughput genomic data for possible changes has become one of the most recent applications of statistical change point analysis.  This type of statistical analysis is evidently crucial in cancer research, clinical diagnostic applications, etc.   In this talk, I present a new change point detection method for the detection of CNVs using the next-generation sequencing data.

        专家简介：
        陈洁，美国乔治亚医学院生物统计与流行病学学院教授，主要从事统计学中的生物信息学的研究与教育工作，与美国生物方面的专家进行合作，研究统计在生物信息学中的模型建立。已发表SCI论文50余篇，其中包括Science, ProcNatlAcadSci U S A, Bioinformatics, Blood, Circulation-Cardiovascular Imaging, BMC Bioinformatics等国际著名期刊。

        主办单位：

       重庆大学理学部
       重庆大学生物工程学院
       重庆大学“111计划”创新引智基地
       生物流变科学与技术教育部重点实验室